Do Synthetic Nicotine Vapes Taste Different?

Pure nicotine is flavorless and odorless but develops a slightly bitter, acidic flavor when exposed to air and light. It is an unpleasant taste at best and disgusting at worst. That’s why we rarely see flavorless vape liquids other than a base liquid to which flavor is added later.

Plant-derived nicotine is less pure than Synthetic Nicotine, so the bitter flavor might be more pronounced. You would almost certainly taste the difference if no other flavor was added. But it is doubtful that you would be able to notice a difference between a flavored liquid that uses Synthetic Nicotine and one that uses “natural” nicotine unless that added flavor was very subtle.